Priligy: The Science and Uses
| Characteristic | Details |
|---|---|
| Active Ingredient | Dapoxetine |
| Available Dosages | 30 mg, 60 mg |
| Mechanism of Action | Selective serotonin reuptake inhibitor (SSRI) |
| FDA-Approved Indications | Treatment of premature ejaculation |
| Interactions | Contraindicated with MAOIs, SSRIs, and thioridazine |
| Toxicity | Dose-dependent, mild to moderate side effects |
| More Information | |
Mechanism of Action
Priligy 60 mg employs dapoxetine, a selective serotonin reuptake inhibitor (SSRI). It augments serotonin levels in the synapse. This modulation delays ejaculatory latency. The action is rapid, distinguishing it from other SSRIs. Its pharmacokinetics suit acute administration. Dapoxetine binds extensively to plasma proteins. Its metabolism occurs in the liver, mediated by CYP2D6 and CYP3A4 enzymes. The resulting metabolites are inactive. Elimination is through the renal pathway, completing the pharmacological cycle. The drug acts primarily on the central nervous system. Its serotonergic modulation translates to a delayed ejaculatory reflex. This targets the primary symptom of premature ejaculation.
FDA-Approved Indications
Priligy 30 mg has secured approval specifically for premature ejaculation. This condition is characterized by a reduced latency to orgasm. It affects interpersonal relationships and self-esteem. Clinical trials underpin its efficacy. It is effective in enhancing control over ejaculation. It also improves sexual satisfaction. The therapeutic regimen is situational. Patients take the medication one to three hours before intercourse. This timing capitalizes on its quick action. The episodic nature of administration minimizes chronic exposure. Studies indicate it extends intravaginal ejaculatory latency time (IELT). It also shows favorable outcomes in patient-reported measures.
Priligy Interactions
Priligy 30 mg interacts with a range of pharmaceutical agents. Monoamine oxidase inhibitors (MAOIs) pose a severe risk when combined. SSRIs and SNRIs, due to their overlapping mechanisms, may cause serotonergic toxicity. Thioridazine, an antipsychotic, also interacts negatively. Caution is warranted with CYP3A4 inhibitors, which can elevate dapoxetine levels. This could amplify side effects. Alcohol consumption alongside Priligy should be limited. It may intensify central nervous system effects. Grapefruit juice could similarly alter metabolism.
Toxicity
Dapoxetine 60 mg exhibits a dose-dependent side effect profile. Common adverse reactions include nausea and dizziness. Headache and insomnia also appear frequently. Severe events are rare but may include syncope. Overdose could potentiate these reactions. The therapeutic window allows for adequate management of symptoms. Patients should adhere strictly to prescribed dosages. Any deviation should be clinically justified. The transient nature of side effects is noted. They typically resolve without intervention. However, continuous monitoring is advisable.
Priligy for Sale Online
Priligy 30 mg is available through various online platforms. Its sale is regulated, necessitating a prescription. This control ensures patient safety. Online pharmacies offer convenience and discretion. Authenticity and licensing of the supplier are critical. Buyers should verify these credentials. Consultations prior to purchase are recommended. This ensures suitability for the individual’s health status. Market availability extends across global boundaries. Pricing varies, with potential for competitive offers. Consumers should remain informed on regulations. This ensures compliance and security in transactions.
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